Projects
| Project | Title | Principal Investigators |
|---|---|---|
| Project Area A: Scientific Projects | ||
|
Structural and functional organization of endocytic scaffolds within the periactive zone |
Haucke (FMP; FUB) Maritzen (FMP) |
|
|
In vivo analysis of active zone assembly |
Sigrist (FUB) Petzoldt (FUB) |
|
|
Spatiotemporal model of neuronal signaling and its regulation by presynaptic membrane scaffolds |
Noé (FUB) |
|
|
The Role of the Rim-binding protein AZ scaffold in regulating neurotransmitter release at diverse central synapses |
Rosenmund (NWFZ, CHA) Schmitz (CHA) |
|
|
Organization of the synaptic active zone scaffold by Bruchpilot and RIM-binding protein |
Wahl (FUB) Sigrist (FUB) |
|
|
Regulation of SH3 domain-based scaffolds in clathrin-mediated endocytosis |
Freund (FUB) Haucke (FMP; FUB) |
|
|
Scaffolding of mechanotransduction domains in migratinfg and non-migrating cells |
Lewin (MDC) Hammes-Lewin (MDC) |
|
|
Functional analysis of septin scaffolds assembled at the plasma membrane during cytokinesis |
Krauß(FMP) Ewers (FUB) |
|
| Structural and functional examinations of nucleotide-dependent membrane scaffolds |
Daumke (MDC) |
|
|
Golgi-associated protein scaffolds regulating receptor targeting and hormone secretion |
Schürmann (DIfE) |
|
|
A PRG2-PTEN based membrane scaffold involved in the formation of axon branches |
Eickholt (CHA) |
|
|
Protein scaffolds in synaptic endomembrane degradation |
Hiesinger (FUB) |
|
|
Synaptic scaffold proteins regulate presynaptic proteostasis |
Garner (DZNE) |
|
|
Functional regulation of post-synaptic scaffold proteins |
Shoichet (CHA) |
|
|
A global role of alternative splicing in the secretory pathway: The COPII scaffold and beyond |
Heyd (FUB) | |
|
Investigating the role of the membrane-associated Cerebral Cavernous Malformations (CCM) protein scaffold in biomechanical signaling |
Seyfried (UP) | |
|
Nanoscale organization of adaptor scaffolds involved in polarized cargo sorting at the trans-Golgi network (TGN) |
Bottanelli (FUB) | |
|
Modeling mechanisms of membrane shaping, fusionn, and fission in endo- and exocytosis by protein scaffolds |
Kozlov (TAU) | |
|
Synaptic scaffolds regulating cholinergic Drosophila synapses |
Owald (CHA) | |
| Project Area Z: Central Projects, Graduate Training and Administration | ||
|
Advanced and super-resolution imaging to resolve the nanoscale structure and dynamics of membrane scaffolds |
Schmoranzer(CHA) Ewers (FUB) |
|
|
Proteomics platform for protein interaction mapping |
Freund (FUB) Liu (FMP) |
|
|
Three-dimensional cryo-electron microscopy |
Spahn (CHA) | |
| Module Public Relations | ||
|
Reflecting on the nature of science using examples from the SFB 958 |
Skiebe-Corrette (FUB) Krüger (FUB) |
|
| Graduate Training | ||
|
Integrated Research Training Group |
Ewers (FUB) |
|
| Administration | ||
|
Central Tasks - SFB Office and Administration |
Sigrist (FUB) |
|
CHA: Charité - Universitätsmedizin Berlin
DIfE: German Institute for Nutrition Research
DZNE: Deutsches Zentrum für Neurodegenerative Erkrankungen
FMP: Leibniz-Institut für Molekulare Pharmakologie
FUB: Freie Universität Berlin
MDC: Max-Delbrück-Center for Molecular Medicine
NWFZ: Neuroscience Research Center at the Charité
UP: Universität Potsdam